CYBB

GENE INFORMATION

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Gene name

CYBB (HGNC Symbol)

Synonyms

CGD, GP91-PHOX, NOX2

Description

cytochrome b-245, beta polypeptide (HGNC Symbol)

Entrez gene summary

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

p11.4

Chromosome location (bp)

37639264 - 37672714

Ensembl

ENSG00000165168 (version 73.37)

Entrez gene

1536

UniProt

P04839 (UniProt - Evidence at protein level)

neXtProt

NX_P04839

Antibodypedia

CYBB antibodies
 

PROTEIN VIEW

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CYBB-001
 
CYBB-201
 
CYBB-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYBB-001 ENSP00000367851
ENST00000378588
P04839
Show all »
Show » Show » 570 65.3 No 7
CYBB-201 ENSP00000441958
ENST00000536160
F5GWU5
Show all »
Show » Show » 303 35.1 No 1
CYBB-202 ENSP00000441896
ENST00000545017
F5GWD2
Show all »
Show » Show » 538 61.3 No 6