WRN

GENE INFORMATION

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Gene name

WRN (HGNC Symbol)

Synonyms

RECQ3, RECQL2

Description

Werner syndrome, RecQ helicase-like (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008]

Chromosome

8 (Chromosome progress)

Cytoband

p12

Chromosome location (bp)

30891317 - 31031285

Ensembl

ENSG00000165392 (version 73.37)

Entrez gene

7486

UniProt

Q14191 (UniProt - Evidence at protein level)

neXtProt

NX_Q14191

Antibodypedia

WRN antibodies
 

PROTEIN VIEW

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WRN-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

WRN-001 ENSP00000298139
ENST00000298139
Q14191
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