RET

GENE INFORMATION

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Gene name

RET (HGNC Symbol)

Synonyms

CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51

Description

ret proto-oncogene (HGNC Symbol)

Entrez gene summary

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

Chromosome

10 (Chromosome progress)

Cytoband

q11.21

Chromosome location (bp)

43572475 - 43625799

Ensembl

ENSG00000165731 (version 73.37)

Entrez gene

5979

UniProt

P07949 (UniProt - Evidence at protein level)

neXtProt

NX_P07949

Antibodypedia

RET antibodies
 

PROTEIN VIEW

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RET-001
 
RET-002
 
RET-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RET-001 ENSP00000347942
ENST00000355710
P07949
Show all »
Show » Show » 1114 124.3 Yes 1
RET-002 ENSP00000344798
ENST00000340058
P07949
Show all »
Show » Show » 1072 119.8 Yes 1
RET-003 ENSP00000419080
ENST00000498820
C9JYL6
Show all »
Show » 181 19.4 Yes 1