CASP7

GENE INFORMATION

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Gene name

CASP7 (HGNC Symbol)

Synonyms

CMH-1, ICE-LAP3, MCH3

Description

caspase 7, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

10 (Chromosome progress)

Cytoband

q25.3

Chromosome location (bp)

115438942 - 115490662

Ensembl

ENSG00000165806 (version 73.37)

Entrez gene

840

UniProt

P55210 (UniProt - Evidence at protein level)

neXtProt

NX_P55210

Antibodypedia

CASP7 antibodies
 

PROTEIN VIEW

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CASP7-001
 
CASP7-002
 
CASP7-003
 
CASP7-004
 
CASP7-005
 
CASP7-201
 
CASP7-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP7-001 ENSP00000358324
ENST00000369318
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-002 ENSP00000358321
ENST00000369315
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-003 ENSP00000358337
ENST00000369331
P55210
Show all »
Show » Show » 253 28 No 0
CASP7-004 ENSP00000400094
ENST00000429617
Q5SVL2
Show all »
Show » 222 24.8 No 0
CASP7-005 ENSP00000298701
ENST00000345633
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-201 ENSP00000358327
ENST00000369321
P55210
Show all »
Show » Show » 336 37.8 No 0
CASP7-202 ENSP00000398107
ENST00000452490
P55210
Show all »
Show » Show » 278 31.6 No 0