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GENE INFORMATION

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Gene name

CEP57 (HGNC Symbol)

Synonyms

KIAA0092, Translokin, TSP57

Description

centrosomal protein 57kDa (HGNC Symbol)

Entrez gene summary

This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

11 (Chromosome progress)

Cytoband

q21

Chromosome location (bp)

95523129 - 95565857

Ensembl

ENSG00000166037 (version 69.37)

Entrez gene

9702

UniProt

Q86XR8

neXtProt

NX_Q86XR8

Antibodypedia

CEP57 antibodies
 

PROTEIN VIEW

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 « 
 
CEP57-001
 
CEP57-002
 
CEP57-004
 
CEP57-006
 
CEP57-007
 
CEP57-008
 
CEP57-009
 
CEP57-010
 
CEP57-011
 
CEP57-012
 
CEP57-013
 
CEP57-201
 
CEP57-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CEP57-001 ENSP00000317902
ENST00000325542
Q86XR8
Show all »
Show » Show » 500 57.1 No 0
CEP57-002 ENSP00000441392
ENST00000537677
F5GYW0
Show all »
Show » 473 54.5 No 0
CEP57-004 ENSP00000445706
ENST00000538658
Q86XR8
Show all »
Show » Show » 270 31.1 No 0
CEP57-006 ENSP00000437422
ENST00000539855
F5H6R3
Show all »
Show » Show » 82 8.8 Yes 0
CEP57-007 ENSP00000440996
ENST00000540830
F5GXS6
Show all »
Show » Show » 71 7.6 Yes 0
CEP57-008 ENSP00000443866
ENST00000538095
F5GZ93
Show all »
52 5.5 No 0
CEP57-009 ENSP00000438065
ENST00000544522
F5H0C6
Show all »
Show » 198 23.2 No 0
CEP57-010 ENSP00000442481
ENST00000535497
F5H7J4
Show all »
Show » 41 4.7 No 0
CEP57-011 ENSP00000445821
ENST00000541365
F5H1B0
Show all »
Show » 205 24.2 No 0
CEP57-012 ENSP00000444749
ENST00000537093
H0YGT4
Show all »
Show » 134 15 No 0
CEP57-013 ENSP00000440256
ENST00000535224
254 28.7 No 0
CEP57-201 ENSP00000317487
ENST00000325486
Q86XR8
Show all »
Show » Show » 474 54.2 No 0
CEP57-202 ENSP00000443436
ENST00000541150
F5H5F7
Show all »
Show » 491 56.5 No 0