C2

GENE INFORMATION

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Gene name

C2

Synonyms

Description

complement component 2 (HGNC Symbol)

Entrez gene summary

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]

Chromosome

6 (Chromosome progress)

Cytoband

p21.33

Chromosome location (bp)

31865562 - 31913449

Ensembl

ENSG00000166278 (version 73.37)

Entrez gene

717

UniProt

P06681 (UniProt - Evidence at protein level)

neXtProt

NX_P06681

Antibodypedia

C2 antibodies
 

PROTEIN VIEW

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 « 
 
C2-001
 
C2-002
 
C2-003
 
C2-004
 
C2-006
 
C2-007
 
C2-008
 
C2-009
 
C2-010
 
C2-011
 
C2-012
 
C2-014
 
C2-015
 
C2-017
 
C2-018
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

C2-001 ENSP00000299367
ENST00000299367
P06681
Show all »
Show » Show » 752 83.3 Yes 0
C2-002 ENSP00000406190
ENST00000418949
Q8N6L6
Show all »
Show » 328 35.5 Yes 0
C2-003 ENSP00000372664
ENST00000383177
Show » Show » 526 58.8 Yes 0
C2-004 ENSP00000417482
ENST00000497706
E9PDZ0
Show all »
Show » Show » 463 51.4 No 0
C2-006 ENSP00000388727
ENST00000411571
F2Z306
Show all »
84 8.9 No 0
C2-007 ENSP00000403325
ENST00000413154
Q5ST52
Show all »
139 14.8 Yes 0
C2-008 ENSP00000420305
ENST00000484636
F2Z306
Show all »
84 8.9 No 0
C2-009 ENSP00000391354
ENST00000447952
F2Z3N2
Show all »
203 21.7 Yes 0
C2-010 ENSP00000395683
ENST00000442278
P06681
Show all »
Show » Show » 620 69.4 Yes 0
C2-011 ENSP00000419048
ENST00000494905
C9JYQ5
Show all »
136 14.9 No 0
C2-012 ENSP00000417790
ENST00000485690
160 17.9 No 0
C2-014 ENSP00000392322
ENST00000452323
P06681
Show all »
Show » Show » 538 60.3 No 0
C2-015 ENSP00000406121
ENST00000452202
A2ABG0
Show all »
158 17.5 No 0
C2-017 ENSP00000418923
ENST00000469372
B4DQI1
Show all »
Show » Show » 506 56.5 No 0
C2-018 ENSP00000418332
ENST00000482060
F8WCJ9
Show all »
Show » 104 10.8 Yes 0