MAPK7

GENERAL INFORMATION

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Gene name

MAPK7

Gene description

Mitogen-activated protein kinase 7

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate cytoplasmic and occasional nuclear positivity. Strong staining was observed in pancreas, adrenal cortex, gastrointestinal tract and skeletal muscle. Renal glomeruli were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB018561
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAPK7 (HGNC Symbol)

Synonyms

BMK1, ERK5, PRKM7

Description

Mitogen-activated protein kinase 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

19377721 - 19383544

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166484 (version 78.38)

Entrez gene

5598

UniProt

Q13164 (UniProt - Evidence at protein level)

neXtProt

NX_Q13164

Antibodypedia

MAPK7 antibodies


PROTEIN BROWSER

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ENST00000299612
 
ENST00000308406
 
ENST00000395602
 
ENST00000395604
 
ENST00000443215
 
ENST00000482850
 
ENST00000579284
 
ENST00000603493
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK7-001 ENSP00000378966
ENST00000395602
Q13164
Show all »
Show » Show » 816 88.4 No 0
MAPK7-002 ENSP00000378968
ENST00000395604
Q13164
Show all »
Show » Show » 816 88.4 No 0
MAPK7-003 ENSP00000299612
ENST00000299612
Q13164
Show all »
Show » Show » 677 73.2 No 0
MAPK7-004 ENSP00000458146
ENST00000482850
I3L0J8
Show all »
Show » Show » 196 22.6 No 0
MAPK7-005 ENSP00000412902
ENST00000443215
C9JUK9
Show all »
Show » Show » 241 27.2 No 0
MAPK7-015 ENSP00000462819
ENST00000579284
J3KT61
Show all »
Show » Show » 157 17.2 No 0
MAPK7-018 ENSP00000474397
ENST00000603493
S4R3I1
Show all »
Show » Show » 144 15.6 No 0
MAPK7-201 ENSP00000311005
ENST00000308406
Q13164
Show all »
Show » Show » 816 88.4 No 0