MAPK7

GENE INFORMATION

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Gene name

MAPK7 (HGNC Symbol)

Synonyms

BMK1, ERK5, PRKM7

Description

mitogen-activated protein kinase 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

p11.2

Chromosome location (bp)

19281034 - 19286857

Ensembl

ENSG00000166484 (version 73.37)

Entrez gene

5598

UniProt

Q13164 (UniProt - Evidence at protein level)

neXtProt

NX_Q13164

Antibodypedia

MAPK7 antibodies
 

PROTEIN VIEW

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MAPK7-001
 
MAPK7-002
 
MAPK7-003
 
MAPK7-004
 
MAPK7-005
 
MAPK7-015
 
MAPK7-016
 
MAPK7-018
 
MAPK7-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPK7-001 ENSP00000378966
ENST00000395602
Q13164
Show all »
Show » Show » 816 88.4 No 0
MAPK7-002 ENSP00000378968
ENST00000395604
Q13164
Show all »
Show » Show » 816 88.4 No 0
MAPK7-003 ENSP00000299612
ENST00000299612
Q13164
Show all »
Show » Show » 677 73.2 No 0
MAPK7-004 ENSP00000458146
ENST00000482850
I3L0J8
Show all »
Show » 196 22.6 No 0
MAPK7-005 ENSP00000412902
ENST00000443215
C9JUK9
Show all »
Show » 241 27.2 No 0
MAPK7-015 ENSP00000462819
ENST00000579284
J3KT61
Show all »
Show » 157 17.2 No 0
MAPK7-016 ENSP00000462804
ENST00000581260
J3KT50
Show all »
Show » 80 8.4 No 0
MAPK7-018 ENSP00000474397
ENST00000603493
Show » 144 15.6 No 0
MAPK7-201 ENSP00000311005
ENST00000308406
Q13164
Show all »
Show » Show » 816 88.4 No 0