PRKCB

GENE INFORMATION

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Gene name

PRKCB (HGNC Symbol)

Synonyms

PKCB, PRKCB1, PRKCB2

Description

protein kinase C, beta (HGNC Symbol)

Entrez gene summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

p12.1

Chromosome location (bp)

23847322 - 24231932

Ensembl

ENSG00000166501 (version 73.37)

Entrez gene

5579

UniProt

P05771 (UniProt - Evidence at protein level)

neXtProt

NX_P05771

Antibodypedia

PRKCB antibodies
 

PROTEIN VIEW

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PRKCB-001
 
PRKCB-002
 
PRKCB-003
 
PRKCB-004
 
PRKCB-007
 
PRKCB-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRKCB-001 ENSP00000318315
ENST00000321728
P05771
Show all »
Show » Show » 671 76.9 No 0
PRKCB-002 ENSP00000305355
ENST00000303531
P05771
Show all »
Show » Show » 673 77 No 0
PRKCB-003 ENSP00000454428
ENST00000498058
P05771
Show all »
Show » Show » 57 6.4 No 0
PRKCB-004 ENSP00000459227
ENST00000498739
I3L1Z0
Show all »
Show » 119 13.8 No 0
PRKCB-007 ENSP00000457980
ENST00000472066
H3BV73
Show all »
Show » 130 14.9 No 0
PRKCB-010 ENSP00000458564
ENST00000466124
Show » 122 14 No 0