TK2

GENE INFORMATION

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Gene name

TK2

Synonyms

Description

Thymidine kinase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

Chromosome

16

Cytoband

q21

Chromosome location (bp)

66541906 - 66586447

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166548 (version 75.37)

Entrez gene

7084

UniProt

O00142 (UniProt - Evidence at protein level)

neXtProt

NX_O00142

Antibodypedia

TK2 antibodies
 

PROTEIN VIEW

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 « 
 
TK2-001
 
TK2-002
 
TK2-003
 
TK2-004
 
TK2-005
 
TK2-006
 
TK2-007
 
TK2-008
 
TK2-009
 
TK2-014
 
TK2-016
 
TK2-017
 
TK2-019
 
TK2-201
 
TK2-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TK2-001 ENSP00000414334
ENST00000451102
O00142
Show all »
Show » Show » 265 31 No 0
TK2-002 ENSP00000433770
ENST00000527800
B4DZK7
Show all »
Show » Show » 168 20.3 No 0
TK2-003 ENSP00000434594
ENST00000525974
B4DZK7
Show all »
Show » Show » 168 20.3 No 0
TK2-004 ENSP00000435312
ENST00000527284
O00142
Show all »
Show » Show » 234 27.6 No 0
TK2-005 ENSP00000407469
ENST00000417693
O00142
Show all »
Show » Show » 247 28.9 No 0
TK2-006 ENSP00000464313
ENST00000569718
Show » Show » 142 16.4 No 0
TK2-007 ENSP00000457959
ENST00000567357
H3BV57
Show all »
Show » Show » 120 13.3 No 0
TK2-008 ENSP00000438143
ENST00000545043
O00142
Show all »
Show » Show » 240 28.4 No 0
TK2-009 ENSP00000463560
ENST00000563369
B4DZK7
Show all »
Show » Show » 168 20.3 No 0
TK2-014 ENSP00000455187
ENST00000564917
H3BP77
Show all »
Show » Show » 282 32.9 No 0
TK2-016 ENSP00000462341
ENST00000563478
J3KS73
Show all »
Show » Show » 130 15.8 No 0
TK2-017 ENSP00000463326
ENST00000562484
J3QL12
Show all »
Show » Show » 89 10.7 No 0
TK2-019 ENSP00000462721
ENST00000561905
Show » 22 2.4 No 0
TK2-201 ENSP00000299697
ENST00000299697
E5KNQ5
Show all »
Show » Show » 307 35.4 No 0
TK2-202 ENSP00000440898
ENST00000544898
F5GYK4
Show all »
Show » Show » 216 25.5 No 0