CHRFAM7A

GENE INFORMATION

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Gene name

CHRFAM7A (HGNC Symbol)

Synonyms

CHRNA7-DR1, D-10

Description

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion (HGNC Symbol)

Entrez gene summary

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

30653443 - 30686052

Ensembl

ENSG00000166664 (version 73.37)

Entrez gene

89832

UniProt

Q494W8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q494W8

Antibodypedia

CHRFAM7A antibodies
 

PROTEIN VIEW

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CHRFAM7A-001
 
CHRFAM7A-002
 
CHRFAM7A-004
 
CHRFAM7A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRFAM7A-001 ENSP00000385389
ENST00000401522
Q693P7
Show all »
Show » Show » 321 35.5 No 4
CHRFAM7A-002 ENSP00000299847
ENST00000299847
Q494W8
Show all »
Show » Show » 412 46.2 No 4
CHRFAM7A-004 ENSP00000455401
ENST00000562729
H3BPP0
Show all »
Show » 104 12.1 No 0
CHRFAM7A-201 ENSP00000380927
ENST00000397827
Q693P7
Show all »
Show » Show » 321 35.5 No 4