B2M

GENERAL INFORMATION

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Gene name

B2M

Gene description

Beta-2-microglobulin

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA006361 , CAB002572
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

B2M

Synonyms

Description

Beta-2-microglobulin (HGNC Symbol)

Entrez gene summary

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

Chromosome

15

Cytoband

q21.1

Chromosome location (bp)

44711477 - 44718877

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166710 (version 78.38)

Entrez gene

567

UniProt

P61769 (UniProt - Evidence at protein level)

neXtProt

NX_P61769

Antibodypedia

B2M antibodies


PROTEIN BROWSER

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ENST00000544417
 
ENST00000558401
 
ENST00000559916
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

B2M-001 ENSP00000452780
ENST00000558401
P61769
Show all »
Show » Show » 119 13.7 Yes 0
B2M-006 ENSP00000453350
ENST00000559916
P61769
Show all »
Show » Show » 119 13.7 Yes 0
B2M-201 ENSP00000437604
ENST00000544417
Q9UM88
Show all »
Show » 101 11.7 Yes 0