HTR3A

GENE INFORMATION

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Gene name

HTR3A (HGNC Symbol)

Synonyms

5-HT3A, 5-HT3R, HTR3

Description

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q23.2

Chromosome location (bp)

113845603 - 113861035

Ensembl

ENSG00000166736 (version 73.37)

Entrez gene

3359

UniProt

P46098 (UniProt - Evidence at protein level)

neXtProt

NX_P46098

Antibodypedia

HTR3A antibodies
 

PROTEIN VIEW

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HTR3A-001
 
HTR3A-002
 
HTR3A-003
 
HTR3A-004
 
HTR3A-201
 
HTR3A-202
 
HTR3A-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HTR3A-001 ENSP00000424189
ENST00000504030
P46098
Show all »
Show » Show » 478 55.3 Yes 4
HTR3A-002 ENSP00000424776
ENST00000506841
P46098
Show all »
Show » Show » 510 58.4 Yes 4
HTR3A-003 ENSP00000299961
ENST00000299961
P46098
Show all »
Show » Show » 463 53.8 No 4
HTR3A-004 ENSP00000423653
ENST00000510849
B3VRI0
Show all »
Show » 238 27.4 Yes 0
HTR3A-201 ENSP00000347754
ENST00000355556
P46098
Show all »
Show » Show » 516 59 Yes 4
HTR3A-202 ENSP00000364648
ENST00000375498
P46098
Show all »
Show » Show » 484 55.9 Yes 4
HTR3A-203 ENSP00000437776
ENST00000535865
Q9UEP2
Show all »
Show » Show » 222 25 No 2