ANPEP

GENE INFORMATION

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Gene name

ANPEP (HGNC Symbol)

Synonyms

CD13, gp150, LAP1, p150, PEPN

Description

alanyl (membrane) aminopeptidase (HGNC Symbol)

Entrez gene summary

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q26.1

Chromosome location (bp)

90328120 - 90358633

Ensembl

ENSG00000166825 (version 73.37)

Entrez gene

290

UniProt

P15144 (UniProt - Evidence at protein level)

neXtProt

NX_P15144

Antibodypedia

ANPEP antibodies
 

PROTEIN VIEW

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ANPEP-001
 
ANPEP-002
 
ANPEP-003
 
ANPEP-004
 
ANPEP-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANPEP-001 ENSP00000300060
ENST00000300060
P15144
Show all »
Show » Show » 967 109.5 No 1
ANPEP-002 ENSP00000452934
ENST00000559874
H0YKT6
Show all »
Show » Show » 103 11.1 No 1
ANPEP-003 ENSP00000453413
ENST00000560137
H0YM04
Show all »
Show » Show » 61 6.1 No 1
ANPEP-004 ENSP00000453405
ENST00000560028
H0YLZ8
Show all »
Show » 65 7.2 No 0
ANPEP-005 ENSP00000453545
ENST00000560030
H0YMC1
Show all »
Show » 122 13.3 No 0