STAT6

GENE INFORMATION

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Gene name

STAT6 (HGNC Symbol)

Synonyms

D12S1644, IL-4-STAT

Description

signal transducer and activator of transcription 6, interleukin-4 induced (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

12 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

57489191 - 57525922

Ensembl

ENSG00000166888 (version 73.37)

Entrez gene

6778

UniProt

P42226 (UniProt - Evidence at protein level)

neXtProt

NX_P42226

Antibodypedia

STAT6 antibodies
 

PROTEIN VIEW

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STAT6-001
 
STAT6-002
 
STAT6-003
 
STAT6-004
 
STAT6-006
 
STAT6-007
 
STAT6-008
 
STAT6-010
 
STAT6-013
 
STAT6-014
 
STAT6-015
 
STAT6-017
 
STAT6-018
 
STAT6-019
 
STAT6-020
 
STAT6-021
 
STAT6-022
 
STAT6-023
 
STAT6-024
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT6-001 ENSP00000300134
ENST00000300134
P42226
Show all »
Show » Show » 847 94.1 No 0
STAT6-002 ENSP00000451742
ENST00000556155
P42226
Show all »
Show » Show » 847 94.1 No 0
STAT6-003 ENSP00000438451
ENST00000543873
P42226
Show all »
Show » Show » 847 94.1 No 0
STAT6-004 ENSP00000401486
ENST00000454075
P42226
Show all »
Show » Show » 847 94.1 No 0
STAT6-006 ENSP00000444530
ENST00000537215
P42226
Show all »
Show » Show » 737 81.7 No 0
STAT6-007 ENSP00000451909
ENST00000554764
Q5FBW6
Show all »
Show » Show » 38 4.5 No 0
STAT6-008 ENSP00000445409
ENST00000538913
P42226
Show all »
Show » Show » 737 81.7 No 0
STAT6-010 ENSP00000451074
ENST00000553499
G3V370
Show all »
Show » Show » 154 17.8 No 0
STAT6-013 ENSP00000450428
ENST00000555318
H0YIY2
Show all »
Show » 155 17.3 No 0
STAT6-014 ENSP00000451546
ENST00000553533
Show » Show » 290 32.5 No 0
STAT6-015 ENSP00000450921
ENST00000555375
G3V2X7
Show all »
Show » Show » 154 17.9 No 0
STAT6-017 ENSP00000450510
ENST00000555104
Q5FBW6
Show all »
Show » Show » 38 4.5 No 0
STAT6-018 ENSP00000450732
ENST00000553275
G3V2L2
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Show » Show » 64 7.4 No 0
STAT6-019 ENSP00000451209
ENST00000554825
G3V3E9
Show all »
Show » Show » 103 11.7 No 0
STAT6-020 ENSP00000452203
ENST00000553397
G3V568
Show all »
Show » Show » 144 16.7 No 0
STAT6-021 ENSP00000452394
ENST00000555849
G3V5K5
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Show » Show » 159 18.3 No 0
STAT6-022 ENSP00000450747
ENST00000557635
G3V2M3
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Show » Show » 74 8.3 No 0
STAT6-023 ENSP00000450665
ENST00000554663
G3V2H4
Show all »
Show » Show » 105 11.8 No 0
STAT6-024 ENSP00000452373
ENST00000556259
G3V5I8
Show all »
Show » Show » 141 16.4 No 0