AKTIP

GENE INFORMATION

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Gene name

AKTIP (HGNC Symbol)

Synonyms

FLJ13258, FTS

Description

AKT interacting protein (HGNC Symbol)

Entrez gene summary

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

16 (Chromosome progress)

Cytoband

q12.2

Chromosome location (bp)

53525291 - 53538323

Ensembl

ENSG00000166971 (version 73.37)

Entrez gene

64400

UniProt

Q9H8T0 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H8T0

Antibodypedia

AKTIP antibodies
 

PROTEIN VIEW

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AKTIP-001
 
AKTIP-002
 
AKTIP-003
 
AKTIP-005
 
AKTIP-006
 
AKTIP-007
 
AKTIP-008
 
AKTIP-009
 
AKTIP-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AKTIP-001 ENSP00000378152
ENST00000394657
Q9H8T0
Show all »
Show » Show » 292 33.1 No 0
AKTIP-002 ENSP00000455874
ENST00000570004
Q9H8T0
Show all »
Show » Show » 292 33.1 No 0
AKTIP-003 ENSP00000300245
ENST00000300245
Q9H8T0
Show all »
Show » Show » 293 33.3 No 0
AKTIP-005 ENSP00000456398
ENST00000564497
14 1.7 No 0
AKTIP-006 ENSP00000454269
ENST00000568022
H3BM79
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Show » Show » 249 28 No 0
AKTIP-007 ENSP00000454771
ENST00000568596
H3BNB8
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Show » 127 14.2 No 0
AKTIP-008 ENSP00000458118
ENST00000565408
H3BVH0
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Show » Show » 136 15.1 No 0
AKTIP-009 ENSP00000456922
ENST00000570041
H3BSX7
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40 4.5 No 0
AKTIP-010 ENSP00000456418
ENST00000563928
H3BRV2
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Show » Show » 150 16.8 No 0