CRK

GENE INFORMATION

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Gene name

CRK

Synonyms

Description

v-crk avian sarcoma virus CT10 oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

1323983 - 1366456

Ensembl

ENSG00000167193 (version 73.37)

Entrez gene

1398

UniProt

P46108 (UniProt - Evidence at protein level)

neXtProt

NX_P46108

Antibodypedia

CRK antibodies
 

PROTEIN VIEW

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CRK-001
 
CRK-002
 
CRK-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRK-001 ENSP00000300574
ENST00000300574
P46108
Show all »
Show » Show » 304 33.8 No 0
CRK-002 ENSP00000381942
ENST00000398970
P46108
Show all »
Show » Show » 204 22.9 No 0
CRK-003 ENSP00000459505
ENST00000574295
I3L297
Show all »
Show » Show » 223 25.5 No 0