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NORMAL TISSUE

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Expression summary

Cytoplasmic and membranous expression in selected cell types. Caution: Based on antibodies targeting proteins from multiple genes.

Reliability (APE)

Very low

Antibodies in assay

HPA044978, HPA045056
 

Tissue presentation order  

Organ

Cell type

Alphabetical

 

Tissue

Antibody staining

Annotated expression

Central nervous system (Brain)
Cerebral cortex Neuronal cells
Cerebral cortex Endothelial cells
Cerebral cortex Glial cells
Cerebral cortex Neuropil
Hippocampus Neuronal cells
Hippocampus Glial cells
Lateral ventricle Neuronal cells
Lateral ventricle Glial cells
Cerebellum Purkinje cells
Cerebellum Cells in granular layer
Cerebellum Cells in molecular layer
Blood and immune system (Hematopoietic)
Bone marrow Hematopoietic cells
Lymph node Germinal center cells
Lymph node Non-germinal center cells
Tonsil Germinal center cells
Tonsil Non-germinal center cells
Tonsil Squamous epithelial cells
Spleen Cells in white pulp
Spleen Cells in red pulp
Liver and pancreas
Liver Hepatocytes
Liver Bile duct cells
Gallbladder Glandular cells
Pancreas Exocrine glandular cells
Pancreas Islets of Langerhans
Digestive tract (GI-tract)
Oral mucosa Squamous epithelial cells
Salivary gland Glandular cells
Esophagus Squamous epithelial cells
Stomach, upper Glandular cells
Stomach, lower Glandular cells
Duodenum Glandular cells
Small intestine Glandular cells
Appendix Glandular cells
Appendix Lymphoid tissue
Colon Endothelial cells
Colon Glandular cells
Colon Peripheral nerve/ganglion
Rectum Glandular cells
Respiratory system (Lung)
Nasopharynx Respiratory epithelial cells
Bronchus Respiratory epithelial cells
Lung Pneumocytes
Lung Macrophages
Cardiovascular system (Heart and blood vessels)
Heart muscle Myocytes
  
HPA044978
HPA045056
  

Tissue

Antibody staining

Annotated expression

Breast and female reproductive system (Female tissues)
Breast Adipocytes
Breast Glandular cells
Breast Myoepithelial cells
Vagina Squamous epithelial cells
Cervix, uterine Squamous epithelial cells
Cervix, uterine Glandular cells
Uterus, pre-menopause Glandular cells
Uterus, pre-menopause Cells in endometrial stroma
Uterus, post-menopause Glandular cells
Uterus, post-menopause Cells in endometrial stroma
Fallopian tube Glandular cells
Ovary Follicle cells
Ovary Ovarian stroma cells
Placenta
Placenta Trophoblastic cells
Placenta Decidual cells
Male reproductive system (Male tissues)
Testis Cells in seminiferus ducts
Testis Leydig cells
Epididymis Glandular cells
Prostate Glandular cells
Seminal vesicle Glandular cells
Urinary tract (Kidney and bladder)
Kidney Cells in glomeruli
Kidney Cells in tubules
Urinary bladder Urothelial cells
Skin and soft tissues
Soft tissue 1 Adipocytes
Soft tissue 1 Chondrocytes
Soft tissue 1 Fibroblasts
Soft tissue 1 Peripheral nerve
Soft tissue 2 Adipocytes
Soft tissue 2 Chondrocytes
Soft tissue 2 Fibroblasts
Soft tissue 2 Peripheral nerve
Skin Fibroblasts
Skin Keratinocytes
Skin Langerhans
Skin Melanocytes
Vulva/anal skin Epidermal cells
Skeletal muscle Myocytes
Smooth muscle Smooth muscle cells
Endocrine glands
Thyroid gland Glandular cells
Parathyroid gland Glandular cells
Adrenal gland Glandular cells
  
HPA044978
HPA045056
 
 

Antibody HPA044978

 

Antibody HPA045056

 
 
Immunohistochemical staining of human testis shows strong cytoplasmic positivity in cells in seminiferus ducts.
 
Immunohistochemical staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.
 

Summary

A subset of cells in seminiferus tubules and red pulp of spleen displayed strong cytoplasmic and nuclear positivity. Remaining normal tissues were in general weakly stained or negative.   Most normal tissues displayed weak to moderate cytoplasmic staining with additional membranous positivity in a few cases. Small intestine and a subset of lymphoid tissue were strongly positive. Glial cells, mesenchymal cells, cells in seminiferus ducts and bile ducts were mainly negative.  

Validation

The multi-targeting antibody yielding a staining pattern partly consistent with characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein chara
 
The multi-targeting antibody yielding a staining pattern partly consistent with characterization data for at least one of the genes whereas any of the other genes has no available gene/protein characterization data or is contradicted by gene/protein chara
 

Level of antibody staining





Strong
Moderate
Weak
Negative



Level of annotated protein expression





High
Medium
Low
None



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