The Human Protein Atlas

Gene name

IGF2 (HGNC Symbol)

Synonyms

C11orf43, FLJ44734

Description

insulin-like growth factor 2 (somatomedin A) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Chromosome

11 (Chromosome progress)

Cytoband

p15.5

Chromosome location (bp)

2150342 - 2182439

Ensembl

ENSG00000167244 (version 69.37)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IGF2-001

ENSP00000414497
ENST00000416167

P01344
Show all » « Hide

P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin
E3UN46 [Target identity:60%; Query identity:100%]
Insulin-like growth factor II transcript variant 3 isoform 1

Show » « Hide

Candidate cancer biomarkers
Plasma proteins
Potential transmembrane proteins
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Potentially secreted proteins
   Secreted proteins predicted by MDSP
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Mapped to UniProt SWISS-PROT
   UniProt - Evidence at protein level

Show » « Hide

GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-dependent]
GO:0007275 [multicellular organismal development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0030546 [receptor activator activity]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitosis]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]

180

20.1

Yes

IGF2-002

ENSP00000370813
ENST00000381406

P01344
Show all » « Hide

P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin

Show » « Hide

183

20.5

Yes

IGF2-003

ENSP00000370802
ENST00000381395

P01344
Show all » « Hide

Show » « Hide

180

20.1

Yes

IGF2-004

ENSP00000370799
ENST00000381392

P01344
Show all » « Hide

P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin

Show » « Hide

183

20.5

Yes

IGF2-005

ENSP00000402047
ENST00000418738

P01344
Show all » « Hide

Show » « Hide

180

20.1

Yes

IGF2-006

ENSP00000370786
ENST00000381379

P01344
Show all » « Hide

P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin

Show » « Hide

183

20.5

Yes

IGF2-007

ENSP00000391826
ENST00000434045

C9JAF2
Show all » « Hide

C9JAF2 [Target identity:100%; Query identity:100%]
Insulin-like growth factor II
E3UN45 [Target identity:69%; Query identity:100%]
Insulin-like growth factor II transcript variant 3 isoform 2
E3UN46 [Target identity:46%; Query identity:100%]
Insulin-like growth factor II transcript variant 3 isoform 1

Show » « Hide

Potential transmembrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   1TM proteins predicted by MDM

Show » « Hide

GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001649 [osteoblast differentiation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006006 [glucose metabolic process]
GO:0006349 [regulation of gene expression by genetic imprinting]
GO:0006355 [regulation of transcription, DNA-dependent]
GO:0007275 [multicellular organismal development]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0009314 [response to radiation]
GO:0009887 [organ morphogenesis]
GO:0014070 [response to organic cyclic compound]
GO:0030546 [receptor activator activity]
GO:0031017 [exocrine pancreas development]
GO:0031667 [response to nutrient levels]
GO:0032355 [response to estradiol stimulus]
GO:0035094 [response to nicotine]
GO:0038028 [insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042493 [response to drug]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045840 [positive regulation of mitosis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051146 [striated muscle cell differentiation]
GO:0051781 [positive regulation of cell division]
GO:0051897 [positive regulation of protein kinase B signaling cascade]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090031 [positive regulation of steroid hormone biosynthetic process]
GO:2000273 [positive regulation of receptor activity]
GO:2000467 [positive regulation of glycogen (starch) synthase activity]

236

26.3

IGF2-009

ENSP00000370796
ENST00000381389

P01344
Show all » « Hide

Show » « Hide

180

20.1

Yes

IGF2-014

ENSP00000338297
ENST00000337883

P01344
Show all » « Hide

Show » « Hide

180

20.1

Yes

IGF2-201

ENSP00000300632
ENST00000300632

P01344
Show all » « Hide

Show » « Hide

180

20.1

Yes

IGF2-202

ENSP00000370720
ENST00000381319

P01344
Show all » « Hide

P01344 [Direct mapping]
Insulin-like growth factor II Insulin-like growth factor II Insulin-like growth factor II Ala-25 Del Preptin

Show » « Hide

183

20.5

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.