CD3D

GENE INFORMATION

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Gene name

CD3D (HGNC Symbol)

Synonyms

T3D

Description

CD3d molecule, delta (CD3-TCR complex) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Chromosome

11 (Chromosome progress)

Cytoband

q23.3

Chromosome location (bp)

118209669 - 118213459

Ensembl

ENSG00000167286 (version 73.37)

Entrez gene

915

UniProt

P04234 (UniProt - Evidence at protein level)

neXtProt

NX_P04234

Antibodypedia

CD3D antibodies
 

PROTEIN VIEW

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CD3D-001
 
CD3D-002
 
CD3D-003
 
CD3D-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD3D-001 ENSP00000300692
ENST00000300692
P04234
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Show » Show » 171 18.9 Yes 1
CD3D-002 ENSP00000437335
ENST00000529594
E9PMT5
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Show » Show » 98 10.5 Yes 1
CD3D-003 ENSP00000376622
ENST00000392884
P04234
Show all »
Show » Show » 127 14.5 Yes 0
CD3D-005 ENSP00000434794
ENST00000534687
G8H453
Show all »
Show » 132 15 No 0