STIM1

GENE INFORMATION

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Gene name

STIM1 (HGNC Symbol)

Synonyms

D11S4896E, GOK

Description

stromal interaction molecule 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

11 (Chromosome progress)

Cytoband

p15.4

Chromosome location (bp)

3875757 - 4114439

Ensembl

ENSG00000167323 (version 73.37)

Entrez gene

6786

UniProt

Q13586 (UniProt - Evidence at protein level)

neXtProt

NX_Q13586

Antibodypedia

STIM1 antibodies
 

PROTEIN VIEW

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STIM1-001
 
STIM1-002
 
STIM1-003
 
STIM1-004
 
STIM1-005
 
STIM1-006
 
STIM1-007
 
STIM1-010
 
STIM1-015
 
STIM1-016
 
STIM1-017
 
STIM1-018
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STIM1-001 ENSP00000300737
ENST00000300737
Q13586
Show all »
Show » Show » 685 77.4 Yes 1
STIM1-002 ENSP00000436208
ENST00000527651
E9PQJ4
Show all »
Show » Show » 540 62.1 Yes 1
STIM1-003 ENSP00000434767
ENST00000533977
E9PNJ4
Show all »
Show » Show » 512 57.6 No 1
STIM1-004 ENSP00000432210
ENST00000525403
E9PRZ7
Show all »
Show » 110 12.9 No 0
STIM1-005 ENSP00000433949
ENST00000532919
E9PIQ8
Show all »
Show » 139 16.2 No 0
STIM1-006 ENSP00000432383
ENST00000532990
E9PR07
Show all »
Show » 67 7.9 No 0
STIM1-007 ENSP00000431191
ENST00000525055
E9PMB4
Show all »
Show » 83 9.9 No 0
STIM1-010 ENSP00000433266
ENST00000526596
Show » 405 45.3 No 0
STIM1-015 ENSP00000434848
ENST00000532610
E9PN27
Show all »
Show » 133 15.4 No 0
STIM1-016 ENSP00000432378
ENST00000528656
E9PR09
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Show » 117 13.7 No 0
STIM1-017 ENSP00000434200
ENST00000524822
E9PRE4
Show all »
Show » 54 6.3 No 0
STIM1-018 ENSP00000431878
ENST00000530554
E9PJ19
Show all »
Show » 81 9.7 No 0