The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Renal tubules, cells in seminiferus ducts and skeletal myocytes showed strong cytoplasmic positivity. The lung, gastrointestinal glands, gallbladder and Leydig cells showed moderate staining. Plasma and extracellular matrix were positive. Remaining normal tissues were in general negative.
Stomach and myoepithelial cells of breast displayed strong cytoplasmic positivity. Epididymis, fallopian tube and renal glomeruli showed moderate to strong cytoplasmic and membranous staining. Moderate cytoplasmic and nuclear staining was observed in a subset of cells in seminiferus ducts of testis. Respiratory epithelia, endothelial cells, melanocytes, Purkinje cells and heart myocytes exhibited moderate cytoplasmic immunoreactivity. Remaining normal cells were weakly stained or negative.
Most normal tissues showed weak to moderate cytoplasmic positivity. Thyroid gland, keratinocytes, epididymis, prostate and subset of renal tubules were strongly stained. Purkinje cells, pneumocytes, glandular cells of breast, ovary, placental trophoblastic cells, germinal center cells and adipocytes were negative.