AXL

GENE INFORMATION

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Gene name

AXL (HGNC Symbol)

Synonyms

JTK11, UFO

Description

AXL receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

19 (Chromosome progress)

Cytoband

q13.2

Chromosome location (bp)

41725108 - 41767671

Ensembl

ENSG00000167601 (version 73.37)

Entrez gene

558

UniProt

P30530 (UniProt - Evidence at protein level)

neXtProt

NX_P30530

Antibodypedia

AXL antibodies
 

PROTEIN VIEW

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AXL-001
 
AXL-002
 
AXL-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AXL-001 ENSP00000301178
ENST00000301178
P30530
Show all »
Show » Show » 894 98.3 Yes 1
AXL-002 ENSP00000351995
ENST00000359092
P30530
Show all »
Show » Show » 885 97.4 Yes 1
AXL-004 ENSP00000471497
ENST00000593513
M0R0W6
Show all »
Show » Show » 626 69.2 No 1