SERPINF2

GENE INFORMATION

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Gene name

SERPINF2 (HGNC Symbol)

Synonyms

A2AP, AAP, ALPHA-2-PI, API, PLI

Description

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

17 (Chromosome progress)

Cytoband

p13.3

Chromosome location (bp)

1646130 - 1658562

Ensembl

ENSG00000167711 (version 73.37)

Entrez gene

5345

UniProt

P08697 (UniProt - Evidence at protein level)

neXtProt

NX_P08697

Antibodypedia

SERPINF2 antibodies
 

PROTEIN VIEW

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SERPINF2-001
 
SERPINF2-002
 
SERPINF2-003
 
SERPINF2-004
 
SERPINF2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SERPINF2-001 ENSP00000371493
ENST00000382061
P08697
Show all »
Show » Show » 491 54.6 Yes 0
SERPINF2-002 ENSP00000402286
ENST00000453066
C9JMH6
Show all »
Show » Show » 255 27.8 Yes 0
SERPINF2-003 ENSP00000402056
ENST00000453723
C9JPV4
Show all »
Show » Show » 264 29.5 Yes 0
SERPINF2-004 ENSP00000403877
ENST00000450523
P08697
Show all »
Show » Show » 427 47.9 Yes 0
SERPINF2-201 ENSP00000321853
ENST00000324015
P08697
Show all »
Show » Show » 491 54.6 Yes 0