KLK4

GENE INFORMATION

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Gene name

KLK4 (HGNC Symbol)

Synonyms

EMSP, EMSP1, KLK-L1, PRSS17, PSTS

Description

Kallikrein-related peptidase 4 (HGNC Symbol)

Entrez gene summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

51409608 - 51413994

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167749 (version 75.37)

Entrez gene

9622

UniProt

Q9Y5K2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5K2

Antibodypedia

KLK4 antibodies
 

PROTEIN VIEW

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KLK4-001
 
KLK4-002
 
KLK4-003
 
KLK4-006
 
KLK4-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK4-001 ENSP00000326159
ENST00000324041
Q9Y5K2
Show all »
Show » Show » 254 27 Yes 0
KLK4-002 ENSP00000469963
ENST00000598305
M0QYN5
Show all »
Show » 71 7.6 No 0
KLK4-003 ENSP00000472091
ENST00000602148
Q5BQA0
Show all »
Show » Show » 75 8 Yes 0
KLK4-006 ENSP00000469769
ENST00000593885
M0QYN5
Show all »
Show » 71 7.6 No 0
KLK4-201 ENSP00000399448
ENST00000431178
Q96RU5
Show all »
Show » 110 11.9 No 0