KLK6

GENE INFORMATION

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Gene name

KLK6 (HGNC Symbol)

Synonyms

Bssp, Klk7, neurosin, PRSS18, PRSS9

Description

kallikrein-related peptidase 6 (HGNC Symbol)

Entrez gene summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

19 (Chromosome progress)

Cytoband

q13.41

Chromosome location (bp)

51461887 - 51472929

Ensembl

ENSG00000167755 (version 73.37)

Entrez gene

5653

UniProt

Q92876 (UniProt - Evidence at protein level)

neXtProt

NX_Q92876

Antibodypedia

KLK6 antibodies
 

PROTEIN VIEW

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KLK6-001
 
KLK6-002
 
KLK6-003
 
KLK6-004
 
KLK6-005
 
KLK6-006
 
KLK6-201
 
KLK6-202
 
KLK6-203
 
KLK6-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK6-001 ENSP00000309148
ENST00000310157
Q92876
Show all »
Show » Show » 244 26.9 Yes 0
KLK6-002 ENSP00000469630
ENST00000597379
Q92876
Show all »
Show » Show » 40 4.3 Yes 0
KLK6-003 ENSP00000366047
ENST00000376851
Q92876
Show all »
Show » Show » 244 26.9 Yes 0
KLK6-004 ENSP00000471948
ENST00000599881
Q92876
Show all »
Show » Show » 40 4.3 Yes 0
KLK6-005 ENSP00000469702
ENST00000599690
M0QYA5
Show all »
69 7.3 No 0
KLK6-006 ENSP00000470482
ENST00000594641
Q92876
Show all »
Show » Show » 244 26.9 Yes 0
KLK6-201 ENSP00000366049
ENST00000376853
E7ETY0
Show all »
Show » Show » 120 13.1 Yes 0
KLK6-202 ENSP00000375684
ENST00000391808
Q92876
Show all »
Show » Show » 137 15.1 No 0
KLK6-203 ENSP00000396012
ENST00000424910
Q92876
Show all »
Show » Show » 40 4.3 Yes 0
KLK6-204 ENSP00000409241
ENST00000456750
Q92876
Show all »
Show » Show » 137 15.1 No 0