RPSA

GENERAL INFORMATION

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Gene name

RPSA

Gene description

Ribosomal protein SA

Protein class

Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal tissues displayed moderate to strong cytoplasmic immunoreactivity. Bile ducts in the liver were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB009561
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RPSA (HGNC Symbol)

Synonyms

37LRP, LAMR1, LRP, p40, SA

Description

Ribosomal protein SA (HGNC Symbol)

Entrez gene summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p22.1

Chromosome location (bp)

39406689 - 39412542

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168028 (version 78.38)

Entrez gene

3921

UniProt

P08865 (UniProt - Evidence at protein level)

neXtProt

NX_P08865

Antibodypedia

RPSA antibodies


PROTEIN BROWSER

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ENST00000301821
 
ENST00000443003
 
ENST00000458478
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPSA-001 ENSP00000346067
ENST00000301821
P08865
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Show » Show » 295 32.9 No 0
RPSA-002 ENSP00000389351
ENST00000443003
P08865
Show all »
Show » Show » 300 33.3 No 0
RPSA-008 ENSP00000410848
ENST00000458478
C9J9K3
Show all »
Show » Show » 264 29.5 No 0