RPSA

GENE INFORMATION

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Gene name

RPSA (HGNC Symbol)

Synonyms

37LRP, LAMR1, LRP, p40, SA

Description

ribosomal protein SA (HGNC Symbol)

Entrez gene summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

p22.1

Chromosome location (bp)

39448180 - 39454033

Ensembl

ENSG00000168028 (version 73.37)

Entrez gene

3921

UniProt

P08865 (UniProt - Evidence at protein level)

neXtProt

NX_P08865

Antibodypedia

RPSA antibodies
 

PROTEIN VIEW

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RPSA-001
 
RPSA-002
 
RPSA-008
 
RPSA-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPSA-001 ENSP00000346067
ENST00000301821
P08865
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Show » Show » 295 32.9 No 0
RPSA-002 ENSP00000389351
ENST00000443003
P08865
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Show » Show » 300 33.3 No 0
RPSA-008 ENSP00000410848
ENST00000458478
C9J9K3
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Show » 264 29.5 No 0
RPSA-009 ENSP00000396716
ENST00000444512
F8WD59
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90 9.8 No 0