FADD

GENE INFORMATION

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Gene name

FADD (HGNC Symbol)

Synonyms

GIG3, MORT1

Description

Fas (TNFRSF6)-associated via death domain (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.3

Chromosome location (bp)

70049269 - 70053496

Ensembl

ENSG00000168040 (version 73.37)

Entrez gene

8772

UniProt

Q13158 (UniProt - Evidence at protein level)

neXtProt

NX_Q13158

Antibodypedia

FADD antibodies
 

PROTEIN VIEW

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FADD-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FADD-001 ENSP00000301838
ENST00000301838
Q13158
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