MAP4K2

GENE INFORMATION

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Gene name

MAP4K2 (HGNC Symbol)

Synonyms

BL44, GCK, RAB8IP

Description

mitogen-activated protein kinase kinase kinase kinase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]

Chromosome

11 (Chromosome progress)

Cytoband

q13.1

Chromosome location (bp)

64556290 - 64570713

Ensembl

ENSG00000168067 (version 73.37)

Entrez gene

5871

UniProt

Q12851 (UniProt - Evidence at protein level)

neXtProt

NX_Q12851

Antibodypedia

MAP4K2 antibodies
 

PROTEIN VIEW

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MAP4K2-001
 
MAP4K2-002
 
MAP4K2-005
 
MAP4K2-006
 
MAP4K2-012
 
MAP4K2-013
 
MAP4K2-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP4K2-001 ENSP00000294066
ENST00000294066
Q12851
Show all »
Show » Show » 820 91.6 No 0
MAP4K2-002 ENSP00000366567
ENST00000377350
Q86VU3
Show all »
Show » Show » 812 90.8 No 0
MAP4K2-005 ENSP00000403410
ENST00000424945
Show » Show » 144 15.9 No 0
MAP4K2-006 ENSP00000403563
ENST00000439069
C9JCU6
Show all »
Show » 307 34.8 No 0
MAP4K2-012 ENSP00000400594
ENST00000435926
F2Z2B3
Show all »
Show » 57 6.3 No 0
MAP4K2-013 ENSP00000404534
ENST00000444560
F8WCP4
Show all »
Show » 58 6.4 No 0
MAP4K2-014 ENSP00000413167
ENST00000433890
F2Z2B3
Show all »
Show » 57 6.3 No 0