PBK

GENERAL INFORMATION

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Gene name

PBK

Gene description

PDZ binding kinase

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Highest expression in trophoblastic cells, in cells of seminiferus ducts and in lymphoid reaction centers.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 1 antibody.
HPA005753
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

PBK (HGNC Symbol)

Synonyms

CT84, FLJ14385, Nori-3, SPK, TOPK

Description

PDZ binding kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

8

Cytoband

p21.1

Chromosome location (bp)

27809620 - 27838095

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168078 (version 78.38)

Entrez gene

55872

UniProt

Q96KB5 (UniProt - Evidence at protein level)

neXtProt

NX_Q96KB5

Antibodypedia

PBK antibodies


PROTEIN BROWSER

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ENST00000301905
 
ENST00000522944
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PBK-001 ENSP00000301905
ENST00000301905
Q96KB5
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Show » Show » 322 36.1 No 0
PBK-002 ENSP00000428489
ENST00000522944
Q96KB5
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Show » Show » 333 37.2 No 0