COPS6

GENE INFORMATION

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Gene name

COPS6 (HGNC Symbol)

Synonyms

CSN6, MOV34-34KD

Description

COP9 signalosome subunit 6 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008]

Chromosome

7 (Chromosome progress)

Cytoband

q22.1

Chromosome location (bp)

99686577 - 99689823

Ensembl

ENSG00000168090 (version 73.37)

Entrez gene

10980

UniProt

Q7L5N1 (UniProt - Evidence at protein level)

neXtProt

NX_Q7L5N1

Antibodypedia

COPS6 antibodies
 

PROTEIN VIEW

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COPS6-001
 
COPS6-004
 
COPS6-005
 
COPS6-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

COPS6-001 ENSP00000304102
ENST00000303904
Q7L5N1
Show all »
Show » Show » 327 36.2 Yes 0
COPS6-004 ENSP00000400617
ENST00000418625
E7EM64
Show all »
Show » Show » 326 36.1 Yes 0
COPS6-005 ENSP00000413702
ENST00000426712
H7C3T0
Show all »
123 13.5 No 0
COPS6-007 ENSP00000388865
ENST00000419210
C9JQK5
Show all »
Show » 42 4.5 No 0