DEGS2

GENERAL INFORMATION

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Gene name

DEGS2

Gene description

Delta(4)-desaturase, sphingolipid 2

Protein class

Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (small intestine)
GTEx:Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein localization

Paneth cells in small intestine showed strong cytoplasmic immunoreactivity. Remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA046644
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skin)

Organ

Expression



GENE INFORMATION

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Gene name

DEGS2 (HGNC Symbol)

Synonyms

C14orf66, DES2, FADS8

Description

Delta(4)-desaturase, sphingolipid 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]

Chromosome

14

Cytoband

q32.2

Chromosome location (bp)

100143957 - 100160163

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168350 (version 78.38)

Entrez gene

123099

UniProt

Q6QHC5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6QHC5

Antibodypedia

DEGS2 antibodies


PROTEIN BROWSER

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ENST00000305631
 
ENST00000553834
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEGS2-001 ENSP00000307126
ENST00000305631
Q6QHC5
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Show » Show » 323 37.2 No 4
DEGS2-002 ENSP00000450637
ENST00000553834
G3V2F9
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Show » 54 5.9 No 0