SCN11A

GENERAL INFORMATION

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Gene name

SCN11A

Gene description

Sodium channel, voltage-gated, type XI, alpha subunit

Protein class

Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (spleen, testis)

Protein evidence

Evidence at protein level

Protein localization

High cytoplasmic expression in the central nervous system, respiratory epithelial cells and gastrointestinal tract.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA036746 , HPA036747
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen, testis)

Organ

Expression



GENE INFORMATION

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Gene name

SCN11A (HGNC Symbol)

Synonyms

NaN, Nav1.9, SCN12A, SNS-2

Description

Sodium channel, voltage-gated, type XI, alpha subunit (HGNC Symbol)

Entrez gene summary

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]

Chromosome

3

Cytoband

p22.2

Chromosome location (bp)

38845769 - 38950561

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168356 (version 78.38)

Entrez gene

11280

UniProt

Q9UI33 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UI33

Antibodypedia

SCN11A antibodies


PROTEIN BROWSER

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ENST00000302328
 
ENST00000444237
 
ENST00000456224
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCN11A-001 ENSP00000307599
ENST00000302328
Q9UI33
Show all »
Show » Show » 1791 204.9 No >9
SCN11A-002 ENSP00000408028
ENST00000444237
Q9UI33
Show all »
Show » Show » 1444 165.7 No >9
SCN11A-003 ENSP00000416757
ENST00000456224
Q9UI33
Show all »
Show » Show » 1753 200.4 No >9