SCN11A

GENE INFORMATION

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Gene name

SCN11A (HGNC Symbol)

Synonyms

NaN, Nav1.9, SCN12A, SNS-2

Description

sodium channel, voltage-gated, type XI, alpha subunit (HGNC Symbol)

Entrez gene summary

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]

Chromosome

3 (Chromosome progress)

Cytoband

p22.2

Chromosome location (bp)

38887260 - 38992052

Ensembl

ENSG00000168356 (version 73.37)

Entrez gene

11280

UniProt

Q9UI33 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UI33

Antibodypedia

SCN11A antibodies
 

PROTEIN VIEW

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SCN11A-001
 
SCN11A-002
 
SCN11A-003
 
SCN11A-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SCN11A-001 ENSP00000307599
ENST00000302328
Q9UI33
Show all »
Show » Show » 1791 204.9 No >9
SCN11A-002 ENSP00000408028
ENST00000444237
Q9UI33
Show all »
Show » Show » 1444 165.7 No >9
SCN11A-003 ENSP00000416757
ENST00000456224
Q9UI33
Show all »
Show » Show » 1753 200.4 No >9
SCN11A-201 ENSP00000400945
ENST00000450244
Q9UI33
Show all »
Show » Show » 1791 204.9 No >9