ATG4B

GENERAL INFORMATION

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Gene name

ATG4B

Gene description

Autophagy related 4B, cysteine peptidase

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General nuclear and cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB037195
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATG4B (HGNC Symbol)

Synonyms

APG4B, AUTL1, DKFZp586D1822, KIAA0943

Description

Autophagy related 4B, cysteine peptidase (HGNC Symbol)

Entrez gene summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.3

Chromosome location (bp)

241637213 - 241673857

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168397 (version 78.38)

Entrez gene

23192

UniProt

Q9Y4P1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y4P1

Antibodypedia

ATG4B antibodies


PROTEIN BROWSER

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ENST00000400771
 
ENST00000402096
 
ENST00000404914
 
ENST00000405546
 
ENST00000419606
 
ENST00000425239
 
ENST00000428861
 
ENST00000429899
 
ENST00000430617
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATG4B-001 ENSP00000383964
ENST00000405546
Q9Y4P1
Show all »
Show » Show » 380 42.6 No 0
ATG4B-002 ENSP00000384259
ENST00000404914
Q9Y4P1
Show all »
Show » Show » 393 44.3 No 0
ATG4B-006 ENSP00000384661
ENST00000402096
Q9Y4P1
Show all »
Show » Show » 331 37 No 0
ATG4B-015 ENSP00000400050
ENST00000419606
C9J1C1
Show all »
Show » Show » 66 7.7 No 0
ATG4B-020 ENSP00000407389
ENST00000430617
C9JVD5
Show all »
Show » Show » 105 12.1 No 0
ATG4B-023 ENSP00000409895
ENST00000425239
C9JQ72
Show all »
Show » Show » 266 30.2 No 0
ATG4B-025 ENSP00000383582
ENST00000400771
C9JIK8
Show all »
Show » Show » 219 24.8 No 0
ATG4B-026 ENSP00000410526
ENST00000429899
C9J3C0
Show all »
Show » Show » 147 16.6 No 0
ATG4B-027 ENSP00000404783
ENST00000428861
H7C2A6
Show all »
Show » Show » 193 21.2 No 0