STAT3

GENE INFORMATION

? »

Gene name

STAT3 (HGNC Symbol)

Synonyms

APRF

Description

signal transducer and activator of transcription 3 (acute-phase response factor) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

17 (Chromosome progress)

Cytoband

q21.2

Chromosome location (bp)

40465342 - 40540586

Ensembl

ENSG00000168610 (version 73.37)

Entrez gene

6774

UniProt

P40763 (UniProt - Evidence at protein level)

neXtProt

NX_P40763

Antibodypedia

STAT3 antibodies
 

PROTEIN VIEW

? »
 
 
 
STAT3-001
 
STAT3-002
 
STAT3-011
 
STAT3-012
 
STAT3-013
 
STAT3-016
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT3-001 ENSP00000264657
ENST00000264657
P40763
Show all »
Show » Show » 770 88.1 No 0
STAT3-002 ENSP00000384943
ENST00000404395
P40763
Show all »
Show » Show » 769 88 No 0
STAT3-011 ENSP00000467985
ENST00000588969
P40763
Show all »
Show » Show » 770 88.1 No 0
STAT3-012 ENSP00000467000
ENST00000585517
K7ENL3
Show all »
Show » Show » 722 83.1 No 0
STAT3-013 ENSP00000373923
ENST00000389272
G8JLH9
Show all »
Show » Show » 672 76.1 No 0
STAT3-016 ENSP00000467173
ENST00000588065
K7EP08
Show all »
Show » 84 10.2 No 0