IL7R

GENE INFORMATION

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Gene name

IL7R (HGNC Symbol)

Synonyms

CD127

Description

Interleukin 7 receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p13.2

Chromosome location (bp)

35852797 - 35879705

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168685 (version 75.37)

Entrez gene

3575

UniProt

P16871 (UniProt - Evidence at protein level)

neXtProt

NX_P16871

Antibodypedia

IL7R antibodies
 

PROTEIN VIEW

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IL7R-001
 
IL7R-002
 
IL7R-003
 
IL7R-004
 
IL7R-006
 
IL7R-007
 
IL7R-009
 
IL7R-010
 
IL7R-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL7R-001 ENSP00000306157
ENST00000303115
P16871
Show all »
Show » Show » 459 51.6 Yes 1
IL7R-002 ENSP00000427688
ENST00000514217
B8YG18
Show all »
Show » Show » 180 20.4 Yes 0
IL7R-003 ENSP00000421207
ENST00000506850
D6RGV2
Show all »
Show » Show » 261 29.9 Yes 0
IL7R-004 ENSP00000426426
ENST00000508941
D6RG28
Show all »
Show » Show » 59 6.4 Yes 0
IL7R-006 ENSP00000425538
ENST00000515665
D6RCR9
Show all »
Show » Show » 52 5.6 Yes 0
IL7R-007 ENSP00000425309
ENST00000511982
D6RDM4
Show all »
Show » Show » 150 16.8 Yes 0
IL7R-009 ENSP00000420923
ENST00000505875
H0Y8G3
Show all »
Show » 209 22.8 No 0
IL7R-010 ENSP00000426069
ENST00000505093
H0YA41
Show all »
Show » Show » 65 7.7 No 0
IL7R-201 ENSP00000345819
ENST00000343305
D9N160
Show all »
Show » Show » 262 30 Yes 0