IL12A

GENE INFORMATION

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Gene name

IL12A (HGNC Symbol)

Synonyms

CLMF, IL-12A, NFSK, NKSF1, p35

Description

interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

Chromosome

3 (Chromosome progress)

Cytoband

q25.33

Chromosome location (bp)

159706537 - 159713806

Ensembl

ENSG00000168811 (version 73.37)

Entrez gene

3592

UniProt

P29459 (UniProt - Evidence at protein level)

neXtProt

NX_P29459

Antibodypedia

IL12A antibodies
 

PROTEIN VIEW

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IL12A-001
 
IL12A-005
 
IL12A-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL12A-001 ENSP00000303231
ENST00000305579
P29459
Show all »
Show » Show » 253 28.3 No 1
IL12A-005 ENSP00000420184
ENST00000480787
E7ENE1
Show all »
Show » Show » 215 24 No 1
IL12A-006 ENSP00000419046
ENST00000466512
E9PGR3
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Show » Show » 239 26.7 No 1