INPP5D

GENERAL INFORMATION

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Gene name

INPP5D

Gene description

Inositol polyphosphate-5-phosphatase, 145kDa

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

High cytoplasmic expression in lymphoid tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 2 antibodies.
HPA070455 , CAB016300
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

INPP5D (HGNC Symbol)

Synonyms

hp51CN, SHIP

Description

Inositol polyphosphate-5-phosphatase, 145kDa (HGNC Symbol)

Entrez gene summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

233059967 - 233207903

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168918 (version 78.38)

Entrez gene

3635

UniProt

Q92835 (UniProt - Evidence at protein level)

neXtProt

NX_Q92835

Antibodypedia

INPP5D antibodies


PROTEIN BROWSER

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ENST00000359570
 
ENST00000415617
 
ENST00000417661
 
ENST00000445964
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INPP5D-001 ENSP00000352575
ENST00000359570
Q92835
Show all »
Show » Show » 1188 133.2 No 0
INPP5D-006 ENSP00000405338
ENST00000445964
H0Y5Q9
Show all »
Show » Show » 1189 133.3 No 0
INPP5D-013 ENSP00000414835
ENST00000417661
H7C403
Show all »
Show » 130 14 No 0
INPP5D-015 ENSP00000397421
ENST00000415617
H0Y5Q9
Show all »
Show » Show » 810 90.6 No 0