INPP5D

GENE INFORMATION

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Gene name

INPP5D (HGNC Symbol)

Synonyms

hp51CN, SHIP

Description

inositol polyphosphate-5-phosphatase, 145kDa (HGNC Symbol)

Entrez gene summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

2 (Chromosome progress)

Cytoband

q37.1

Chromosome location (bp)

233924677 - 234116549

Ensembl

ENSG00000168918 (version 73.37)

Entrez gene

3635

UniProt

Q92835 (UniProt - Evidence at protein level)

neXtProt

NX_Q92835

Antibodypedia

INPP5D antibodies
 

PROTEIN VIEW

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 « 
 
INPP5D-001
 
INPP5D-002
 
INPP5D-005
 
INPP5D-006
 
INPP5D-013
 
INPP5D-014
 
INPP5D-015
 
INPP5D-201
 
INPP5D-202
 
INPP5D-203
 
INPP5D-204
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INPP5D-001 ENSP00000397421
ENST00000415617
H0Y5Q9
Show all »
Show » Show » 810 90.6 No 0
INPP5D-002 ENSP00000409018
ENST00000422935
C9JLW2
Show all »
Show » Show » 221 24.9 No 0
INPP5D-005 ENSP00000415253
ENST00000451407
C9JF09
Show all »
Show » Show » 222 25 No 0
INPP5D-006 ENSP00000400151
ENST00000435188
H0Y5Q9
Show all »
Show » Show » 810 90.6 No 0
INPP5D-013 ENSP00000414835
ENST00000417661
H7C403
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130 14 No 0
INPP5D-014 ENSP00000473280
ENST00000491070
43 4.5 No 0
INPP5D-015 ENSP00000405338
ENST00000445964
H0Y5Q9
Show all »
Show » Show » 810 90.6 No 0
INPP5D-201 ENSP00000352575
ENST00000359570
Q92835
Show all »
Show » Show » 1177 131.9 No 0
INPP5D-202 ENSP00000407916
ENST00000450745
H7C2V3
Show all »
Show » Show » 941 105.3 No 0
INPP5D-203 ENSP00000404610
ENST00000455936
H7C292
Show all »
Show » Show » 941 105.3 No 0
INPP5D-204 ENSP00000441010
ENST00000538935
F5GXI6
Show all »
Show » Show » 596 67.6 No 0