MAP2K1

GENE INFORMATION

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Gene name

MAP2K1 (HGNC Symbol)

Synonyms

MAPKK1, MEK1, PRKMK1

Description

mitogen-activated protein kinase kinase 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

Chromosome

15 (Chromosome progress)

Cytoband

q22.31

Chromosome location (bp)

66679155 - 66784650

Ensembl

ENSG00000169032 (version 73.37)

Entrez gene

5604

UniProt

Q02750 (UniProt - Evidence at protein level)

neXtProt

NX_Q02750

Antibodypedia

MAP2K1 antibodies
 

PROTEIN VIEW

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MAP2K1-001
 
MAP2K1-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP2K1-001 ENSP00000302486
ENST00000307102
Q02750
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Show » Show » 393 43.4 No 0
MAP2K1-003 ENSP00000456438
ENST00000566326
H3BRW9
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Show » 217 23.9 No 0