KLK7

GENE INFORMATION

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Gene name

KLK7 (HGNC Symbol)

Synonyms

PRSS6, SCCE

Description

kallikrein-related peptidase 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

Chromosome

19 (Chromosome progress)

Cytoband

q13.41

Chromosome location (bp)

51479729 - 51487355

Ensembl

ENSG00000169035 (version 73.37)

Entrez gene

5650

UniProt

P49862 (UniProt - Evidence at protein level)

neXtProt

NX_P49862

Antibodypedia

KLK7 antibodies
 

PROTEIN VIEW

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KLK7-001
 
KLK7-002
 
KLK7-003
 
KLK7-004
 
KLK7-201
 
KLK7-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK7-001 ENSP00000470538
ENST00000595820
P49862
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Show » Show » 253 27.5 Yes 0
KLK7-002 ENSP00000304791
ENST00000304045
Q6DTY1
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66 7.2 Yes 0
KLK7-003 ENSP00000469950
ENST00000597707
P49862
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Show » Show » 181 19.9 No 0
KLK7-004 ENSP00000470084
ENST00000593904
M0QYU8
Show all »
Show » 69 7.8 No 0
KLK7-201 ENSP00000337540
ENST00000336317
B4DHX9
Show all »
Show » 140 15.2 No 0
KLK7-202 ENSP00000375683
ENST00000391807
P49862
Show all »
Show » Show » 253 27.5 Yes 0