AR

GENE INFORMATION

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Gene name

AR (HGNC Symbol)

Synonyms

AIS, DHTR, HUMARA, NR3C4, SBMA, SMAX1

Description

androgen receptor (HGNC Symbol)

Entrez gene summary

The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

X (Chromosome progress)

Cytoband

q12

Chromosome location (bp)

66764465 - 66950461

Ensembl

ENSG00000169083 (version 73.37)

Entrez gene

367

UniProt

P10275 (UniProt - Evidence at protein level)

neXtProt

NX_P10275

Antibodypedia

AR antibodies
 

PROTEIN VIEW

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AR-001
 
AR-002
 
AR-004
 
AR-005
 
AR-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AR-001 ENSP00000363822
ENST00000374690
P10275
Show all »
Show » Show » 920 99.2 No 0
AR-002 ENSP00000379358
ENST00000396043
P10275
Show all »
Show » Show » 388 44.6 No 0
AR-004 ENSP00000421155
ENST00000504326
E7EVX6
Show all »
Show » Show » 644 67.4 No 0
AR-005 ENSP00000425199
ENST00000514029
E9PEG3
Show all »
Show » Show » 600 62.3 No 0
AR-201 ENSP00000379359
ENST00000396044
F5GZG9
Show all »
Show » Show » 734 77 No 0