APEX2

GENE INFORMATION

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Gene name

APEX2 (HGNC Symbol)

Synonyms

APE2, APEXL2, XTH2

Description

APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (HGNC Symbol)

Entrez gene summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

Chromosome

X (Chromosome progress)

Cytoband

p11.21

Chromosome location (bp)

55026790 - 55035490

Ensembl

ENSG00000169188 (version 73.37)

Entrez gene

27301

UniProt

Q9UBZ4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UBZ4

Antibodypedia

APEX2 antibodies
 

PROTEIN VIEW

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APEX2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APEX2-001 ENSP00000364126
ENST00000374987
Q9UBZ4
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