IL13

GENE INFORMATION

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Gene name

IL13 (HGNC Symbol)

Synonyms

ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600

Description

interleukin 13 (HGNC Symbol)

Entrez gene summary

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

Chromosome

5 (Chromosome progress)

Cytoband

q31.1

Chromosome location (bp)

131991955 - 131996802

Ensembl

ENSG00000169194 (version 73.37)

Entrez gene

3596

UniProt

P35225 (UniProt - Evidence at protein level)

neXtProt

NX_P35225

Antibodypedia

IL13 antibodies
 

PROTEIN VIEW

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IL13-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL13-001 ENSP00000304915
ENST00000304506
P35225
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