IL1RAPL1

GENERAL INFORMATION

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Gene name

IL1RAPL1

Gene description

Interleukin 1 receptor accessory protein-like 1

Protein class

Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (hippocampus)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests low expression in cerebral cortex. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending retesting.

Data reliability

Uncertain based on 1 antibody.
HPA000564
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

IL1RAPL1 (HGNC Symbol)

Synonyms

IL1R8, IL1RAPL, MRX10, MRX21, MRX34, OPHN4, TIGIRR-2

Description

Interleukin 1 receptor accessory protein-like 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

Chromosome location (bp)

28587399 - 29956723

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169306 (version 78.38)

Entrez gene

11141

UniProt

Q9NZN1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NZN1

Antibodypedia

IL1RAPL1 antibodies


PROTEIN BROWSER

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ENST00000302196
 
ENST00000378993
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL1RAPL1-001 ENSP00000368278
ENST00000378993
Q9NZN1
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Show » Show » 696 80 Yes 1
IL1RAPL1-201 ENSP00000305200
ENST00000302196
Q7Z2H0
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Show » Show » 437 50.2 No 1