NPR1

GENE INFORMATION

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Gene name

NPR1 (HGNC Symbol)

Synonyms

ANPa, ANPRA, GUCY2A, NPRA

Description

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) (HGNC Symbol)

Entrez gene summary

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Chromosome

1 (Chromosome progress)

Cytoband

q21.3

Chromosome location (bp)

153651113 - 153666468

Ensembl

ENSG00000169418 (version 73.37)

Entrez gene

4881

UniProt

P16066 (UniProt - Evidence at protein level)

neXtProt

NX_P16066

Antibodypedia

NPR1 antibodies
 

PROTEIN VIEW

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NPR1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NPR1-001 ENSP00000357669
ENST00000368680
P16066
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