HTRA4

GENERAL INFORMATION

? »

Gene name

HTRA4

Gene description

HtrA serine peptidase 4

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in placenta.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 1 antibody.
HPA045402
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enriched (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

? »

Gene name

HTRA4 (HGNC Symbol)

Synonyms

FLJ90724

Description

HtrA serine peptidase 4 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]

Chromosome

8

Cytoband

p11.22

Chromosome location (bp)

38974164 - 38988662

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169495 (version 78.38)

Entrez gene

203100

UniProt

P83105 (UniProt - Evidence at transcript level)

neXtProt

NX_P83105

Antibodypedia

HTRA4 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000302495
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HTRA4-001 ENSP00000305919
ENST00000302495
P83105
Show all »
Show » Show » 476 51 Yes 0