BUB1

GENE INFORMATION

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Gene name

BUB1 (HGNC Symbol)

Synonyms

BUB1A, BUB1L, hBUB1

Description

BUB1 mitotic checkpoint serine/threonine kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

2 (Chromosome progress)

Cytoband

q13

Chromosome location (bp)

111395275 - 111435691

Ensembl

ENSG00000169679 (version 73.37)

Entrez gene

699

UniProt

O43683 (UniProt - Evidence at protein level)

neXtProt

NX_O43683

Antibodypedia

BUB1 antibodies
 

PROTEIN VIEW

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BUB1-001
 
BUB1-002
 
BUB1-005
 
BUB1-006
 
BUB1-007
 
BUB1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BUB1-001 ENSP00000302530
ENST00000302759
O43683
Show all »
Show » Show » 1085 122.4 No 0
BUB1-002 ENSP00000386701
ENST00000409311
E9PC26
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Show » Show » 1028 115.8 No 0
BUB1-005 ENSP00000409713
ENST00000420328
C9JRC7
Show all »
Show » 134 16.1 No 0
BUB1-006 ENSP00000392219
ENST00000436916
C9IYH4
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Show » 56 7 No 0
BUB1-007 ENSP00000402883
ENST00000447014
C9JQA4
Show all »
Show » 146 17.5 No 0
BUB1-201 ENSP00000441013
ENST00000535254
F5GXI5
Show all »
Show » Show » 1065 120 No 0